Welcome to Rothstein Publishing!

Motor Disorders, 3rd Edition

This preeminent book in the field of Neurology has been extensively updated and expanded to include 1000+ pages, five major sections and 71 chapters by 70 leading authorities. These provide a single, encyclopedic yet scholarly summary of the scientific advances and new clinical practices for immediate consideration in patient care. It brings together nearly the entire spectrum of motor disorders and Neurology into one convenient resource for comprehensive evaluation, diagnosis, distinction, and treatment of various disorders. Additionally, by using the perspectives of different subspecialties, the book also provides a comprehensive yet concise account of any disorder with motor manifestations.




In the eight years since Motor Disorders was last published, the Neurosciences have experienced dramatic advances, especially in Neurogenetics, Neuroimmunology, Neurophysiology, Neuroimaging, Neuropharmacology and Neurorehabilitation.

Edited by David S. Younger, MD, a highly respected practitioner and researcher, with scholarly chapters by leaders in the field and more international authors than other texts.

This new edition now includes the following content and features:

  • Up-to-date articles on highly changing subjects related to Neurogenetics.
  • Chapters on Neurorehabilitation – coverage not usually found in other neurological textbooks.
  • Advances in Alzheimer Disease, Parkinson Disease, Amyotophic Lateral Sclerosis.
  • Both adult and pediatric topics in one book.
  • High quality figures of neuroimaging and neuropathology.

Designed for a wide range of Physicians, Nurses, Allied Health Professionals, and Students:

  • Neurologists, Neurophysiologists, and Neuropathologists.
  • Neurological nurses.
  • Physical and Neurorehabilitative Medicine specialists.
  • Medical students, postgraduate Residents in areas of Internal Medicine, Neurology, Rehabilitation Medicine, Neurosurgery, Genetics and Pediatrics.

This 3rd Edition is the most international, comprehensive, and practical volume of current Neurology and Neuromuscular disorders. Dr. Younger is Co-Director of the Muscular Dystrophy Clinic at White Plains Hospitals in New York; Clinical Associate Professor of Neurology at New York University School of Medicine in the Department of Neurology; as well as Attending Physician in Neurology at Lenox Hill Hospital, New York.




About the Author

David S. Younger, M.D., is Co-Director of the Muscular Dystrophy Clinic at White Plains Hospitals in New York; Clinical Associate Professor of Neurology at New York University School of Medicine in the Department of Neurology; as well as Attending Physician in Neurology at Lenox Hill Hospital, New York.David Younger

Having received his medical degree from the College of Physicians and Surgeons of Columbia University, and numerous postgraduate fellowships in Internal Medicine, Clinical Neurophysiology, Electrodiagnostic Medicine, and Neurology, he has returned to New York University to finish a Masters in Public Health and an Epidemiology Masters at Columbia University.

Recognized for his expertise in numerous fields related to Motor Disorders, he has authored more than 200 articles, book chapters, literature reviews, and other published works. As Associate Editor of the Seminars in Neurology, he focused on motor disorders and conceptualized the 1st edition of Motor Disorders in 1999, later focusing on the blueprints for the 2nd and 3rd Editions.



Contributing Authors

Preface to the Third Edition

Foreword by Michael J. Aminoff, M.D.


  1. Correlative Neuroanatomy
    David S. Younger
  2. Brain Neuroimaging
    Eytan Raz, Nisha Mehta, Yvonne W. Lui
  3. Spinal Cord Neuroimaging
    Keivan Shifteh, Jacqueline A. Bello
  4. Neurophysiology of Clinical Motor Control
    Christopher W. Hess, Seth L. Pullman
  5. Electrodiagnostic Studies in Motor Disorders
    Mark A. Ferrante
  6. Electrophysiology of the Motor Unit
    Stefano Simonetti, Miki Nikolic, Christian Krarup
  7. Autonomic Electrophysiological Assessment
    Joel Gutiérrez
  8. Muscle and Nerve Biopsy Pathology
    Umberto De Girolami, Pedro Ciarlini, Anthony A. Amato, David S. Younger
  9. Cytopathology and Ultrastructure of CNS Motor Diseases
    Hirofumi Kusaka, David S. Younger, Asao Hirano
  10. Neurogenetic Evaluation of Motor Disorders
    Gregory M. Pastores, Heather A. Lau
  11. Neurologic Hereditary Metabolic Diseases of Infancy and Childhood
    David S. Younger
  12. Vertigo and Vestibular Disorders
    David S. Younger
  13. Laryngeal Motor Disorders
    David S. Younger
  14. Vasculitis of the Nervous System
    David S. Younger
  15. Clinical Research Parameters in Neuromuscular Disease
    Richard J. Barohn, Laura Herbelin, Mazen M. Dimachki


  1. Isolated and Multiple Cranial Nerve Palsies
    David S. Younger
  2. The Hypotonic Infant
    Thornton B.A. Mason II, Darryl C. De Vivo
  3. Inflammatory Myopathies
    David S. Younger, Marinos C. Dalakas
  4. Metabolic Myopathies
    Michio Hirano, Salvatore DiMauro
  5. Childhood Muscular Dystrophies
    David S. Younger
  6. Distal Myopathies
    Mazen M. Dimachkie, Richard J. Barohn
  7. The Channelopathies
    David S. Younger, Michael Rose, Robert C. Griggs
  8. Facioscapulohumeral Muscular Dystrophy
    David S. Younger
  9. Myalgia, Fibromyalgia, Fasciculation, and Cramps
    David S. Younger
  10. Myasthenia Gravis and Myasthenic Syndromes
    Mark B. Bromberg
  11. Entrapment Neuropathies
    David S. Younger
  12. Plexus Disorders
    David S. Younger
  13. Diabetic Neuropathy
    David S. Younger
  14. Multifocal Motor Neuropathy
    Suraj A. Muley, Gareth J. Parry
  15. Charcot-Marie-Tooth Disorders
    Gregory M. Pastores, David S. Younger
  16. Acute Inflammatory Demyelinating Polyneuropathy
    Mazen M. Dimachkie, Richard J. Barohn
  17. Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Related Disorders
    Mazen M. Dimachkie, Richard J. Barohn
  18. Lyme Neuroborreliosis
    David S. Younger
  19. Motor Neuropathy and Monoclonal
    Thomas H. Brannagan III, Norman Latov
  20. Critical Illness Disorders
    David S. Younge


  1. Rupture of an Intervertebral Disc and Related Disorders
    David S. Younger
  2. Vitamin B12 (Cobalamin) Deficiency
    David S. Younger
  3. Hereditary Spastic Paraplegia
    David S. Younger
  4. Tropical Myeloneuropathy
    Gustavo C. Roman
  5. Motor Dysfunction in Multiple Sclerosis
    Jonathan E. Howard
  6. Hereditary Cerebellar Ataxia
    David S. Younger
  7. Cervical Spondylotic Myelopathy
    David S. Younger
  8. Spinal Cord and Foramen Magnum Tumors
    David S. Younger, James M. Powers
  9. Spinal Vascular Malformations
    Paul P. Huan


  1. Cerebral Vascular Malformations
    Christina Hadzitheodoro, David S. Younger, Paul P. Huang
  2. Brain Tumors
    David S. Younger
  3. Childhood Spinal Muscular Atrophy
    David S. Younger, Jennifer Werely
  4. Genetic Basis of Familial Amyotrophic Lateral Sclerosis
    Paloma Gonzalez-Perez, Robert H. Brown, Jr.
  5. Amyotrophic Lateral Sclerosis
    Tamara S. Greene, Erika P. Simpson, Stanley H. Appel
  6. Parkinsonian Syndromes and Multisystem
    Samay Jain, Steven J. Frucht
  7. Poliomyelitis and the Post-Polio Syndrome
    Burk Jubelt, Laura Simionescu
  8. Paraneoplastic Disorders and Motor Dysfunction
    Myrna R. Rosenfeld, Josep Dalmau
  9. Human Immunodeficiency Virus Infection
    David S. Younger
  10. Growth Factors and Signals: Impact on Neurological Systems
    Douglas W. Zochodne
  11. Adult and Childhood Hydrocephalus
    David S. Younger
  12. Stroke and Motor Disorders
    David S. Younger
  13. Motor Sequela of Dementia
    Gayatri Devi
  14. Motor Disorders in Epilepsy
    Anurudha Sing


  1. Traumatic Brain Injury
    Michal E. Eisenberg, Brian Im
  2. Traumatic Spinal Cord Injury
    Barry Rodstein, David S. Younger
  3. Stroke Rehabilitation
    Jung Ahn, John-Ross Rizzo, Ana-Marie Rojas
  4. Principles of Neuromuscular Rehabilitation
    John R. Bach
  5. Orthoses and Adaptive Equipment
    Barry Rodstein
  6. Respiratory Muscle Aids
    John R. Bach
  7. Motor Aspects of Childhood Sleep Disorders
    Thornton B.A. Mason II
  8. Evaluation and Management of Swallowing and Voice Disorders
    Celia F. Stewart, Andrew Blitzer
  9. Bladder, Bowel, and Sexual Disorders
    David S. Younger
  10. Motor Disorders Associated with Cerebral Palsy
    Jilda N. Vargus-Adams, Jacob A. Neufeld, Pasquale Accardo
  11. Management of Spasticity
    James W. Stark, Saud A. Sadiq
  12. Botulinum Toxin for Motor Disorders
    David M. Swope, Ehsan Hadi, Mitchell F. Brin
  13. Multidisciplinary Integrated Psychosocial and Palliative Care
    Steven M. Alber



This new edition of Motor Disorders will become widely accepted as a standard work of reference. I welcome its publication, recommend it with enthusiasm, and congratulate Dr. Younger for producing such an outstanding volume.

The book has expanded since the last edition and now contains 71 chapters written by 70 authors and divided into five sections. The individual authors—many of whom are internationally recognized experts—have critically appraised the latest developments in their field while also providing a thorough clinical account of various motor disorders. The editor, Dr. David Younger, is a Clinical Associate Professor of Neurology at the New York University School of Medicine and an Attending Physician at its affiliated acute-care teaching hospital in Manhattan. He is a well-respected clinician, teacher, and clinical investigator who has authored studies on different aspects of neurological function, focusing mainly on the peripheral nervous system and neuromuscular function. His breadth of knowledge, as reflected by the fact that he authored or coauthored 33 of the chapters in this book, has made him a particularly skilled editor of the present volume.

This new—third—edition cements and enhances the reputation gained by earlier editions and continues to provide a detailed and practical account of motor disorders that will appeal to specialists, general physicians, and trainees while providing a convenient but thorough summary of advances in the field. It provides updates both of technological advances and of the fundamental basis of motor disorders, and translates these into clinical practice.

The intent of the book is to bring together the entire spectrum of motor disorders and thereby aid in the evaluation, diagnosis, and distinction of these various disorders. In fact, it does far more than that, providing an account of any disorder with motor manifestations, and doing so through the perspective of many different subspecialties to provide a truly comprehensive but concise account of the subject matter.

Michael J. Aminoff, M.D., DSc, FRCP

Professor and Executive Vice Chair, Neurology

Past Editor, Muscle & Nerve, University of California San Francisco